| DB ID | MyCo_3821 |
| Title | Evaluation of serum 25-hydroxyvitamin D, C-reactive protein, and haptoglobin as biomarkers in dogs newly diagnosed with histoplasmosis |
| Year | 2023 |
| PMID | 36748822 |
| Fungal Diseases involved | Histoplasmosis |
| Associated Medical Condition | None |
| Genus | Histoplasma |
| Species | spp. |
| Organism | Histoplasma spp. |
| Ethical Statement | This study was conducted in accordance with guidelines for clinical studies and approved by the following institutions' Animal Care and Use Committee (KSU-VHC, 4153; OSU-VHT, VM-18-27; MU-CVM, 9567; Midwestern University College of Veterinary Medicine [MWU-CVM], 2993). |
| Site of Infection | Lungs |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Animal |
| Host Common name | Dog |
| Host Scientific name | Canis lupus familiaris |
| Biomarker Name | 25(OH)D |
| Biomarker Full Name | 25-hydroxyvitamin (OH)D |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | United States |
| Cohort | A prospective case-control study was performed. Dogs with a diagnosis of histoplasmosis between December 2018 and June 2020 presented to Kansas State University Veterinary Health Center (KSU-VHC), Oklahoma State University Veterinary Teaching Hospital (OSU-VHT), University of Missouri College of Veterinary Medicine (MU-CVM), and The Ohio State University College of Veterinary Medicine (OSU-CVM) were eligible for inclusion. |
| Cohort No. | 22 (12 - Infected, 10 - Control) |
| Age Group | None |
| P Value | p<.001 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Histoplasmosis is a common invasive fungal infection of dogs worldwide. Spores from the causative fungus, Histoplasma spp., are inhaled after contaminated soil is aerosolized. After inhalation, microconidia convert to the yeast form in the terminal bronchioles of the lungs. Clinical disease in dogs can be limited to the lungs, or disseminate via blood and lymphatics to a wide array of extra-pulmonary sites. |
| Technique | Liquid chromatography |
| Analysis Method | HPLC Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | HPLC, ELISA |
| Up Regulation Down Regulation | Decrease |
| Sequence Data | None |
| External Link | None |
