| DB ID | MyCo_3796 |
| Title | Evaluation of local trace element status and 8-Iso-prostaglandin F2α concentrations in patients with Tinea pedis |
| Year | 2016 |
| PMID | 26740800 |
| Fungal Diseases involved | Tinea pedis |
| Associated Medical Condition | None |
| Genus | Trichophyton |
| Species | mentagrophytes |
| Organism | Trichophyton mentagrophytes |
| Ethical Statement | The study was approved by the local ethical committee of Sutcu Imam University, Medical Faculty, Kahramanmaras, Turkey. Prior to the initiation of the study, each subject was informed about the aim of the study and signed an informed consent form. |
| Site of Infection | Feet |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Tissue Supernatant |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | Cu |
| Biomarker Full Name | Copper |
| Biomarker Type | Diagnostic |
| Biomolecule | Mineral |
| Geographical Location | Turkey |
| Cohort | Forty-three patients were included in the study. Twentynine were female (54.5 %) and 14 were male (44.5 %). The mean age of patients was 40.0 ± 10.2 years (range, 21–58.0). The mean disease duration was 4.2 ± 1.0 months (range, 3–6.0). Strains of Trichophyton rubrum (55), Trichophyton mentagrophytes (35) and Epidermophyton floccosum (10 %) were found from the cultures. |
| Cohort No. | 43 |
| Age Group | None |
| P Value | p<0.05 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Dermatophyte infections are common disorders worldwide, and the incidence of their has increased considerably during the past several decades. Tinea pedis (TP), which is a dermatophytic infection of the feet, can involve the interdigital web spaces or the sides of the feet and may be a chronic or recurring condition. It is generally confined to the stratum corneum in the epidermis and cutaneous appendages. The ability of certain fungi to adhere to a particular host arises from numerous mechanisms and host factors, including the ability to adapt to the human body. The physical and chemical structure of the skin represents a form of defense against fungal pathogens. Neutrophils and monocytes/macrophages appear to be important in the defense against fungi, including those involved in the cutaneous mycoses. Neutrophils can directly attack pathogens by a variety of microbicidal processes. The neutrophil oxidative mechanisms are capable of killing Trichophyton sp. in vitro, suggesting that they could have a role in the defense against dermatophytosis. This mechanism may be active against the organisms causing superficial fungal infections also. |
| Technique | Analytic |
| Analysis Method | Graphite furnace atomic absorption spectrophotometer analysis Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA, Graphite furnace atomic absorption spectrophotometer analysis |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
