| DB ID | MyCo_3745 |
| Title | Early diagnosis and treatment of invasive pulmonary aspergillosis in a patient with cystic fibrosis |
| Year | 2013 |
| PMID | 24248318 |
| Fungal Diseases involved | Invasive pulmonary aspergillosis |
| Associated Medical Condition | cystic fibrosis |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Sputum sample |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | GM |
| Biomarker Full Name | Galactomannan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | Here present the case of a 12-year-old boy with CF who was admitted for an exacerbation which was unresponsive to antibiotic therapy. |
| Cohort No. | 1 |
| Age Group | 12 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive pulmonary aspergillosis (IPA) can occur in patients with immunodeficiencies or corticosteroid- induced immunosuppression. Despite the fact that Aspergillus can be found in up to 60% of cystic fibrosis (CF) patients’ airways, invasive aspergillosis is a very rare and fatal complication. Invasive aspergillosis can be diagnosed with serology like the galactomannan (GM) test, which is negative in patients with CF colonised with Aspergillus. |
| Technique | Assay |
| Analysis Method | GM Assay |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | GM Assay |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
