| DB ID | MyCo_3727 |
| Title | Genetic control of susceptibility to Candida albicans in susceptible A/J and resistant C57BL/6J mice |
| Year | 2005 |
| PMID | 16079897 |
| Fungal Diseases involved | Candida albicans infection |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | All housing and experimental procedures were approved by the Biotechnology Research Institute (BRI) Animal Care Committee, operating under the guidelines of the Canadian Council of Animal Care. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted DNA |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | D2Mit458 |
| Biomarker Full Name | D2Mit458 |
| Biomarker Type | Diagnostic |
| Biomolecule | Gene |
| Geographical Location | Canada |
| Cohort | Inbred, pathogen-free 8- to 12-week-old A/J and C57BL/ 6J (B6) mice were purchased from The Jackson Labora- tory (Bar Harbor, ME, USA). [A/J B6] F2 progeny were bred by systematic brother–sister mating of [A/J B6] F1 mice. The AcB/BcA RCS were purchased from Emerillon Therapeutics (Montreal, Quebec, Canada). |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Candida albicans normally exists as a relatively benign in the gastrointestinal and genitourinary tracts of healthy humans, although in certain immuno- compromised hosts it has the ability to enter into the bloodstream and colonize various organs, including the kidney, digestive tract, lung, and brain. This opportu- nistic fungal pathogen is a major causative agent of nosocomial infections, accounting for up to 15% of hospital-acquired infections in intensive care units. With an overall prognosis comparable to septic shock with multiple organ failure, systemic candidiasis is a life threatening infection. |
| Technique | Bioinformatics analysis |
| Analysis Method | Genotyping analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Genotyping analysis |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
