| DB ID | MyCo_3720 |
| Title | Study of common functional genetic polymorphisms of FCGR2A, 3A and 3B genes and the risk for cryptococcosis in HIV-uninfected patients |
| Year | 2007 |
| PMID | 17710620 |
| Fungal Diseases involved | Cryptococcosis |
| Associated Medical Condition | None |
| Genus | Cryptococcus |
| Species | neoformans |
| Organism | Cryptococcus neoformans |
| Ethical Statement | Cases were collected under a protocol approved by the institutional review board of NCI. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | FCGR2A 131RR |
| Biomarker Full Name | Fc gamma receptor FCGR2A 131RR |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | A total of 103 incident cases of cryptococcosis were collected between 1999 and 2004 from the University ofAlabama at Birmingham, Birmingham, AL; University of Southern California and Los Angeles County Hospital, Los Angeles, CA; Baylor College of Medi- cine, Houston, TX. |
| Cohort No. | 103 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Cryptococcus neoformans is a ubiquitous pathogenic yeast that causes life-threatening infections in immu- nocompromised hosts, including those with AIDS and other underlying disorders such as corticosteroid treatment, transplantation, cancer and sarcoidosis. In a substantial percentage of HIV-negative patients, no identifiable risk factors are observed. The role of innate immunity against C. neoformans is critical, especially since alveolar macrophages first encounter inhaled pathogens and are activated to ingest and kill, partly by producing proinflammatory cytokines. T-cells, macrophages, neutrophils and other cells of immune system express low affinity Fc gamma receptors, which couple humoral and cellular immunity. |
| Technique | Bioinformatics analysis |
| Analysis Method | Genotype and haplotype analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Genotype and haplotype analysis |
| Up Regulation Down Regulation | Over Expressed |
| Sequence Data | None |
| External Link | None |
