| DB ID | MyCo_3695 |
| Title | Protective role of interleukin-10 promoter gene polymorphism in the pathogenesis of invasive pulmonary aspergillosis after allogeneic stem cell transplantation |
| Year | 2005 |
| PMID | 16247433 |
| Fungal Diseases involved | Invasive pulmonary aspergillosis |
| Associated Medical Condition | Allogeneic stem cell transplantation |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | The current study was approved by the Institutional Research Board of Kyungpook National University Hospital and each patient gave written informed consent. |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | IL-10 ACC |
| Biomarker Full Name | Interleukin-10 ACC |
| Biomarker Type | Diagnostic |
| Biomolecule | Gene |
| Geographical Location | Korea |
| Cohort | A total of 105 consecutive adult patients who had under- gone allogeneic SCT at Kyungpook National University Hospital (Daegu, Korea) between Aug 1998 and October 2004 were included in this retrospective study. |
| Cohort No. | 105 |
| Age Group | 16-58 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive pulmonary aspergillosis (IPA), characterized by hyphal invasion and destruction of pulmonary tissue, is a frequent opportunistic infection in patients receiving allo- geneic stem cell transplantation (SCT) with an incidence of nearly 10%.1 The important predisposing conditions for IPA are known to be neutropenia,2 intensive immuno- suppression, and graft-versus-host disease (GVHD). |
| Technique | Bioinformatics analysis |
| Analysis Method | Gene polymorphism study |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Gene polymorphism study |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
