| DB ID | MyCo_3529 |
| Title | Plasma 1,3-β-d-glucan levels predict adverse clinical outcomes in critical illness |
| Year | 2021 |
| PMID | 34128840 |
| Fungal Diseases involved | Candidiasis |
| Associated Medical Condition | Acute respiratory failure (ARF) |
| Genus | Candida |
| Species | spp. |
| Organism | Candida spp. |
| Ethical Statement | The University of Pittsburgh IRB approved the studies (STUDY19050099, STUDY20040036, and STUDY20120028), and written informed consent was provided by all participants or their surrogates in accordance with the Declaration of Helsinki. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Plasma |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | BDG |
| Biomarker Full Name | 1-3-beta-D-Glucan |
| Biomarker Type | Prognostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | Here analyzed data from 453 mechanically ventilated patients with acute respiratory failure (ARF; discovery cohort), who were consecutively enrolled from ICUs at the University of Pittsburgh Medical Center (UPMC). |
| Cohort No. | 453 |
| Age Group | None |
| P Value | p<0.001 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Dysregulation of innate immunity is a central pathogenetic feature of the heterogeneous syndromes of sepsis and acute respiratory distress syndrome (ARDS). In several independent populations, patients with elevated systemic levels of inflammatory cytokines and biomarkers of tissue injury (classified as a hyperinflammatory subphenotype) exhibit worse organ dysfunction and clinical outcomes compared with their hypoinflammatory counterparts. Such biological subphenotyping of critically ill patients offers improved risk prediction over stratification with clinical variables alone and presents new opportunities for targeted pharmacological interventions. However, the molecular mechanisms of aberrant innate immunity stimulation and resultant tissue injury remain largely undefined. |
| Technique | Assay |
| Analysis Method | Fungitell assay |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Fungitell assay |
| Up Regulation Down Regulation | None |
| Sequence Data | None |
| External Link | None |
