| DB ID | MyCo_3484 |
| Title | T-cell dysfunction as a potential contributing factor in post-COVID-19 mucormycosis |
| Year | 2022 |
| PMID | 36305225 |
| Fungal Diseases involved | Mucormycosis |
| Associated Medical Condition | COVID-19 |
| Genus | None |
| Species | None |
| Organism | None |
| Ethical Statement | Ethical approval was taken by the Institutional Ethics Committee, King George's Medical University, Lucknow, India. |
| Site of Infection | None |
| Opportunistic invasive | Invasive/Opportunistic |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CD8+ CD69+ (% CD8+) |
| Biomarker Full Name | CD8+ CD69+ (% CD8+) |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | India |
| Cohort | The study included thirteen patients each of histopathologically proven post-¬ COVID mucor and non-¬ COVID mucor respectively. Fifteen age and sex matched healthy individual (HI) were also included as control. The study included histopathologically confirmed cases of mucor (13 post-¬ COVID, 13 non-¬ COVID) and 15 healthy individuals (HI). |
| Cohort No. | 26 patients and 15 control |
| Age Group | None |
| P Value | p=.001 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Mucormycosis is an invasive fungal disease caused by inhalation of sporangiospores of order mucorales. It is distributed worldwide and associated with the increased morbidity and mortality. The exact prevalence of mucor in India is unknown but the estimated disease burden is approximately 70 times higher than the global prevalence. The most common causative agent is Rhizopus arrhizus (also known as oryzae) and less common are Lichtheimia, Apophysomyces, Rhizomucor and Cunninghamella. |
| Technique | Analytic |
| Analysis Method | Flow Cytometry Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Flow Cytometry Analysis |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
