| DB ID | MyCo_3443 |
| Title | Systemic and local characterization of regulatory T cells in a chronic fungal infection in humans |
| Year | 2006 |
| PMID | 17056505 |
| Fungal Diseases involved | Paracoccidioidomycosis |
| Associated Medical Condition | None |
| Genus | Paracoccidioides |
| Species | brasiliensis |
| Organism | Paracoccidioides brasiliensis |
| Ethical Statement | The experimental protocol used was approved by Institutional Review Board of School of Medicine (Ribeira ˜o Preto). Informed consent was ob- tained from all subjects before performing the studies. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | TNFR |
| Biomarker Full Name | TNFR |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | Leukocytes from blood obtained from 34 untreated patients recently diag- nosed with an active chronic form of PCM (all men; age range: 21–71 years) were enrolled in this study. |
| Cohort No. | 34 |
| Age Group | 21-71 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | One of the most important endemic diseases in Latin America is paracoccidioidomycosis (PCM), a deep granulomatous mycosis caused by the dimorphic fungus Paracoccidioides brasiliensis. The infection, acquired by in- halation of conidia produced by the mycelial phase of the fungus, affects the lungs and can spread to multiple organs via the lym- phatic system and bloodstream. The disease presents a broad spec- trum of clinical and pathological manifestations, ranging from lo- calized lesions to severely disseminated infection. In the endemic areas, surveys with the paracoccidioidin skin test show that many individuals that recognize the fungus Ags are only in- fected, without any manifestation of disease. These chronic infected individuals have persistent Ag stimulation in vivo and develop an apparent effective control of fungal growth and dis- semination. Other patients develop the acute form of the disease. The acute form (or juvenile) of this mycosis is very severe and mimics a systemic lymphoproliferative disease. The chronic form (or adult) is the most frequent clinical presentation of the disease, which is commonly due to reactivation of infection from quiescent foci. |
| Technique | Analytic |
| Analysis Method | Flow Cytometry Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Flow Cytometry Analysis |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
