| DB ID | MyCo_3433 |
| Title | Intercellular adhesion molecule-1 is required for the early formation of granulomas and participates in the resistance of mice to the infection with the fungus Paracoccidioides brasiliensis |
| Year | 2006 |
| PMID | 17003484 |
| Fungal Diseases involved | Paracoccidioidomycosis |
| Associated Medical Condition | None |
| Genus | Paracoccidioides |
| Species | brasiliensis |
| Organism | Paracoccidioides brasiliensis |
| Ethical Statement | All animal experiments were performed in accordance with protocols approved by the School of Medicine of Ribeira ˜o Preto Institutional Animal Care and Use Committee. |
| Site of Infection | Lungs |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted Lungs tissue |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | ICAM-1 |
| Biomarker Full Name | Intercellular Adhesion Molecule-1 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | Male C57BL/6 wild-type mice (WT; ICAM-1 / ) and mice deficient in ICAM-1 (ICAM-1KO; ICAM-1 / ), IFN- (IFN- KO), TNFR1 (p55KO), and IL-12 (IL-12KO), 6 to 8 weeks old in the beginning of the experiments, were used. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Paracoccidioidomycosis, a chronic systemic mycosis that is endemic in Latin America, is caused by the ther- mally dimorphic fungus Paracoccidioides brasiliensis. The disease, acquired by inhalation of the infectious form of the fungus (conidia) present in the environment, has ex-tensive spectrum of clinical and pathological manifesta- tions ranging from benign and localized (adult type) to severe and disseminated forms (juvenile type). Patients with the adult form of paracoccidioidomycosis usually produce low levels of specific antibodies, whereas those with the juvenile type typically show polyclonal B-cell activation and high levels of specific antibodies.1,2 Nev- ertheless, in both cases, the cell-mediated immune re-sponses are abnormal, and absence of specific therapy leads to high mortality. |
| Technique | Analytic |
| Analysis Method | Flow Cytometry Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Flow Cytometry Analysis, ELISA |
| Up Regulation Down Regulation | Up regulated |
| Sequence Data | None |
| External Link | None |
