| DB ID | MyCo_3432 |
| Title | Altered expression of the costimulatory molecules CD80, CD86, CD152, PD-1 and ICOS on T-cells from paracoccidioidomycosis patients: lack of correlation with T-cell hyporesponsiveness |
| Year | 2008 |
| PMID | 18757242 |
| Fungal Diseases involved | Paracoccidioidomycosis |
| Associated Medical Condition | None |
| Genus | Paracoccidioides |
| Species | brasiliensis |
| Organism | Paracoccidioides brasiliensis |
| Ethical Statement | The study protocol was approved by the ethics committees of the Institutions involved in the study. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | ICOS |
| Biomarker Full Name | ICOS |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | A total of 55 patients with recently diagnosed active PCM were consecutively selected at the institutions. |
| Cohort No. | 55 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Paracoccidiodomycosis (PCM) is the most prevalent systemic mycosis in Latin America, with Brazil contributing the highest number of cases, followed by Colombia, Venezuela, and Argentina. It is caused by the dimorphic fungus Paracoc- cidioides brasiliensis. Although it is well accepted that the infection is acquired through inhalation of spores released by the filamentous phase of the fungus present in the soil of endemic areas, the habitat of the fungus remains a puzzle. This mycosis presents a broad spectrum of clinical mani-festations, ranging from localized mucocutaneous lesions to multi-organ involvement, specially of the mononuclear phagocyte system. While associated with low mortality rates, the disease is characterized by its high morbidity, usually requiring long periods of treatment during which the patients remain out of their productive activities. Since the disease predominantly affects male agricultural workers at their most productive ages, between the third and sixth decades, the disease has an important social impact. Re-cently, due to the increased global movements, the number of imported paracoccidioidomycosis cases have become a concern in developed areas of the world. |
| Technique | Analytic |
| Analysis Method | Flow Cytometry Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Flow Cytometry Analysis |
| Up Regulation Down Regulation | Over expressed |
| Sequence Data | None |
| External Link | None |
