| DB ID | MyCo_3426 |
| Title | CD28 exerts protective and detrimental effects in a pulmonary model of paracoccidioidomycosis |
| Year | 2010 |
| PMID | 20713624 |
| Fungal Diseases involved | Paracoccidioidomycosis |
| Associated Medical Condition | None |
| Genus | Paracoccidioides |
| Species | brasiliensis |
| Organism | Paracoccidioides brasiliensis |
| Ethical Statement | Mice were 8 to 11 weeks of age at the time of infection, and procedures involving animals and their care were approved by the Ethics Committee on Animal Experiments from Instituto de Cie ˆncias Biome ´dicas, Universidade de Sa ˜o Paulo. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted Lungs tissue |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | CD28 |
| Biomarker Full Name | CD28 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | Breeding pairs of homozygous CD28-deficient (CD28 / ) and wild-type (WT) control C57BL/6 mice (intermediate susceptibility to P. brasiliensis) were bred at the University of Sa ˜o Paulo animal facilities under specific-pathogen-free (SPF) conditions in closed-top cages. Clean food and water were given ad libitum. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | Analytic |
| Analysis Method | Flow Cytometry Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Flow Cytometry Analysis, ELISA |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
