| DB ID | MyCo_3425 |
| Title | Modulation of CD28 and CD86 expression in patients with paracoccidioidomycosis in different periods of treatment |
| Year | 2004 |
| PMID | 15541043 |
| Fungal Diseases involved | Paracoccidioidomycosis |
| Associated Medical Condition | None |
| Genus | Paracoccidioides |
| Species | brasiliensis |
| Organism | Paracoccidioides brasiliensis |
| Ethical Statement | This study was approved by the ethics committee of the Hospital das Clı ´nicas da Faculdade de Medicina da UFMG, and informed consent was obtained from each subject before blood collection. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CD86 |
| Biomarker Full Name | CD28 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | Patients (age range 18–75 years) recently diagnosed with active PCM from Centro de Treinamento e Refere ˆncia em Doenc ¸as Infecto-Parasita ´rias Orestes Diniz, Hospital das Clı ´nicas da Universidade Federal de Minas Gerais (UFMG)-Brazil were enrolled in this study. |
| Cohort No. | 18–75 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Paracoccidioidomycosis (PCM), caused by the dimorphic fungus Paracoccidioides brasiliensis, is a systemic human mycosis, which is one of the most prevalent in Latin America. The infection is acquired by inhaling air- borne propagules produced by the fungal mycelium form which transforms into the pathogenic yeast form, when at core body temperature. The yeast form can either be eliminated by the cells of the immune system or dissemi-nate to other tissues through lymphatic or hematogenous routes, occasioning several lesions, until death. |
| Technique | Analytic |
| Analysis Method | Flow Cytometry Analysis |
| ELISA kits | ELISA kit (Pharmingen, San Diego, CA, USA) |
| Assay Data | None |
| Validation Techniques used | ELISA,Flow Cytometry Analysis |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
