| DB ID | MyCo_3416 |
| Title | TNF-alpha antagonism generates a population of antigen-specific CD4+CD25+ T cells that inhibit protective immunity in murine histoplasmosis |
| Year | 2008 |
| PMID | 18178849 |
| Fungal Diseases involved | Histoplasmosis |
| Associated Medical Condition | None |
| Genus | Histoplasma |
| Species | capsulatum |
| Organism | Histoplasma capsulatum |
| Ethical Statement | All animal experiments were done in accordance with the Animal Welfare Act guidelines of the National Institutes of Health. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted Lungs tissue |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | TNF-α |
| Biomarker Full Name | Tumor Necrosis Factor alpha |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | C57BL/6 and TCR αβ-/- mice were purchased from The Jackson Laboratory. Animals were housed in isolator cages and were maintained by Department of Laboratory Animal Medicine, University of Cincinnati, which is accredited by the American Association for Accreditation of Laboratory Animal Medicine. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | Analytic |
| Analysis Method | Flow Cytometry Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Flow Cytometry Analysis |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
