| DB ID | MyCo_3413 |
| Title | Fonsecaea pedrosoi infection induces differential modulation of costimulatory molecules and cytokines in monocytes from patients with severe and mild forms of chromoblastomycosis |
| Year | 2008 |
| PMID | 18562487 |
| Fungal Diseases involved | Chromoblastomycosis |
| Associated Medical Condition | None |
| Genus | Fonsecaea |
| Species | pedrosoi |
| Organism | Fonsecaea pedrosoi |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | HLA-DR |
| Biomarker Full Name | HLA-DR |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | Sixteen patients with clinical diagnosis of chromoblastomycosis attended at the Department of Pathology of the Federal University of Maranha ˜o (Brazil) were included in this study. In all cases, diagnosis was confirmed by direct myco- logical examination, culture, and histopathogy. In all cases, the fungus F. pedrosoi was isolated. |
| Cohort No. | 16 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Chromoblastomycosis is a human chronic fungal disease usually limited to s.c. tissues. Infection is initiated by traumatic inoculation of mycelium fragments or conidial cells into the skin by thorns or wood splinters. Chromoblastomycosis usually affects male agricultural workers who are not adequately protected while handling soil and vegetables and de- composing organic matter, which are natural habitats of the fungus. It occurs worldwide but is observed more frequently in tropical countries such as Brazil. |
| Technique | Analytic |
| Analysis Method | Flow Cytometry Analysis |
| ELISA kits | ELISA Kit (BD PharMingen, San Diego, CA, USA). |
| Assay Data | None |
| Validation Techniques used | ELISA, Flow Cytometry Analysis |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
