| DB ID | MyCo_3406 |
| Title | Indinavir-treated Cryptococcus neoformans promotes an efficient antifungal immune response in immunosuppressed hosts |
| Year | 2006 |
| PMID | 16519014 |
| Fungal Diseases involved | Cryptococcus neoformans infection |
| Associated Medical Condition | None |
| Genus | Cryptococcus |
| Species | neoformans |
| Organism | Cryptococcus neoformans |
| Ethical Statement | Procedures involving animals and their care were conducted in con- formity with national and international laws and policies. |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | Indinavir+IL-12 |
| Biomarker Full Name | Indinavir+Interleukin-12 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Italy |
| Cohort | Female, 8/10 weeks old, inbred BALB/c mice were obtained from Harlan Nossan Laboratories (Milan, Italy) and housed at the Animal Facilities of the University of Perugia, Perugia, Italy. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Cryptococcus neoformans is the cause of life-threaten-ing opportunistic infections in immunocompromised subjects including AIDS patients. The host defense against this pathogen is mainly mediated by cellular immunity, and cytokines secreted by type-1 Th cells play a central role in the establishment of protective immunity. These mechanisms usually succeed in restricting the infection within the lung by preventing the pathogenic organism from disseminating to the central nervous system, whereas functional abnormal-ities such as defective interleukin (IL)-12 synthesis facilitate the spread of infection. |
| Technique | Analytic |
| Analysis Method | Flow Cytometry Analysis |
| ELISA kits | ELISA kits (Biosource). |
| Assay Data | None |
| Validation Techniques used | Flow Cytometry Analysis, ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
