| DB ID | MyCo_3401 |
| Title | Chemokine receptor CXCR3 is required for lethal brain pathology but not pathogen clearance during cryptococcal meningoencephalitis |
| Year | 2020 |
| PMID | 32596454 |
| Fungal Diseases involved | Cryptococcal meningoencephalitis |
| Associated Medical Condition | None |
| Genus | Cryptococcus |
| Species | neoformans |
| Organism | Cryptococcus neoformans |
| Ethical Statement | All four patients were seen at the National Institutes of Health (NIH) Clinical Center, Bethesda, MD in 2018 to 2019, and informed con- sent was obtained under an Institutional Review Board–approved protocol (National Institute of Allergy and Infectious Diseases protocol 93-I-0106) for a prospective observational study examin-ing the host genetics and immunology of cryptococcal disease in previously healthy, non–HIV-infected adults. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted tissue |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CXCR3 |
| Biomarker Full Name | CXCR3 |
| Biomarker Type | Negative |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | All four patients were seen at the National Institutes of Health (NIH) Clinical Center, Bethesda, MD in 2018 to 2019, and informed con- sent was obtained under an Institutional Review Board–approved protocol (National Institute of Allergy and Infectious Diseases protocol 93-I-0106) for a prospective observational study examin-ing the host genetics and immunology of cryptococcal disease in previously healthy, non–HIV-infected adults. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | Analytic |
| Analysis Method | Flow Cytometry Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Flow Cytometry Analysis |
| Up Regulation Down Regulation | Negative |
| Sequence Data | None |
| External Link | None |
