| DB ID | MyCo_3398 |
| Title | Compartmentalization of innate immune responses in the central nervous system during cryptococcal meningitis/HIV coinfection |
| Year | 2014 |
| PMID | 24451162 |
| Fungal Diseases involved | Cryptococcal meningitis |
| Associated Medical Condition | HIV-AIDS |
| Genus | Cryptococcus |
| Species | spp. |
| Organism | Cryptococcus spp. |
| Ethical Statement | This study was approved by the University of KwaZulu-Natal Biomedical Research Ethics Committee, the Monash University ethics committee and the University of Western Australia ethics committee. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CXCR3 |
| Biomarker Full Name | CXCR3 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | Here prospectively enrolled consenting cART-naïve, HIV-infected adults with a first-episode of microbiologically- confirmed CM at the King Edward VIII Hospital in Durban, South Africa. Briefly, whole blood and CSF were obtained at enrolment (median 2 days after diagnosis, range 0–8 days) from 23 participants. |
| Cohort No. | 23 |
| Age Group | None |
| P Value | p<0.0001 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Cryptococcal meningitis (CM) is a major cause of morbidity and mortality in patients wit HIV and AIDS. Annually, approximately 957,900 cases of CM occur, resulting in 624,700 deaths by three-months after infection, with sub Saharan Africa bearing the largest burden of disease. The underlying mechanisms causing death and disability include development of persistently high intracranial pressures, vasculopathies, and local brain inflammation with bystander neuronal damage. Both innate and adaptive immune responses contribute to the immunopathogenesis of CM but the regulation and timing of their development remain poorly understood. |
| Technique | Analytic |
| Analysis Method | Flow Cytometry Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Flow Cytometry Analysis |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
