| DB ID | MyCo_3368 |
| Title | Type I interferons promote fatal immunopathology by regulating inflammatory monocytes and neutrophils during Candida infections |
| Year | 2012 |
| PMID | 22911155 |
| Fungal Diseases involved | Fungal sepsis |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | All animal experiments were discussed and approved through the University of Veterinary Medicine Vienna institutional ethics committee and carried out in accordance with animal experimen- tation protocols approved by the Austrian law (GZ 680 205/67- BrGt/2003, GZ-BMWF-68.205/0233-II/10b/2009 and GZ- BMWF-68.205/0231-II/3b/2011). |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Biopsy |
| Sample source | Extracted Kidney tissue |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | PPAR-γ |
| Biomarker Full Name | Peroxisome proliferator-activated receptor-γ |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Austria |
| Cohort | Ifnar12/2 mice on C57BL/6 background [68] were bred at Biomodels Austria, University of Veterinary Medicine. C57BL/6 wild type controls were purchased from Charles River. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Fungal sepsis is a frequent cause of death in the intensive care unit, with Candida spp. being among the most common microbial pathogens isolated from septic patients. Worldwide, C. albicans (Ca) represents the most prevalent isolate recovered from human candidemic patients. The inflammatory response and disease progression of invasive candidiasis presents a similar clinical picture as seen for bacterial sepsis, with some patients developing septic shock and organ dysfunction, the most common of which is acute renal failure. |
| Technique | Analytic |
| Analysis Method | Flow Cytometry Analysis |
| ELISA kits | ELISA Set kit (Biolegend), Mouse CBA flex sets kit (BD Biosciences), Procarta Immunoassays kit(Panomics- Affymetrix) |
| Assay Data | None |
| Validation Techniques used | ELISA, Flow Cytometry Analysis, qRT-PCR |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
