| DB ID | MyCo_3360 |
| Title | Single-cell immune checkpoint landscape of PBMCs stimulated with Candida albicans |
| Year | 2021 |
| PMID | 34120578 |
| Fungal Diseases involved | Candida albicans infection |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | This study was approved by the Clinical Research Ethics Committee of the Peking University First Hos- pital. We obtained blood samples from healthy donors and candidemia patients after obtaining informed consent. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | LY6E |
| Biomarker Full Name | LY6E |
| Biomarker Type | Diagnostic |
| Biomolecule | Gene |
| Geographical Location | China |
| Cohort | None |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | C. albicans accounts for the most frequently isolated pathogen of candidemia, which causes approxi- mately 40% mortality despite antifungal treatment. Moreover, candidemia is a major challenge for healthcare as difficult diagnosis and therapy. For- tunately, as technical development, single-cell RNA- sequencing (scRNA-seq) has been widely used to gen- erate new scientific insights in various fields. Thus, efforts to analyze genomic transcripts of PBMCs stimulated with C. albicans based on single-cell levels will build a foundation for developing novel thera- peutic targets and potential genes with the most rel- evant for C. albicans infection to improve the clinical outcomes of candidemia. |
| Technique | Analytic |
| Analysis Method | Flow Cytometry Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Flow Cytometry Analysis, RNAseq analysis |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
