| DB ID | MyCo_3354 |
| Title | Double positive CD4+CD8+ T cells are part of the adaptive immune response against Candida albicans |
| Year | 2019 |
| PMID | 31561914 |
| Fungal Diseases involved | Candida albicans infection |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | Healthy volunteers were recruited at the blood bank center (Etablissement Français du Sang EFS, Pays de Loire, France). All sub- jects provided written informed consent for research testing in ac- cordance with the Declaration of Helsinki. A convention has been signed between our laboratory (IICiMed, EA1155, Nantes Université) and the EFS (No. NTS-2013-02 and CPDL-PLER-2018-015). |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | IL-4 |
| Biomarker Full Name | Interleukin-4 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | France |
| Cohort | Peripheral blood samples were obtained from sixteen healthy volunteers by venipuncture. C. albicans clinical isolates (Caal93, Caal121 and Caal123) were provided by the Parasitology and Medical Mycology Department, University of Nantes, France. |
| Cohort No. | 16 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Candida albicans is a lifelong colonizer of the human gastrointestinal tract that has evolved to acquire a series of mechanisms to modulate human immune responses. These changes can lead to large genetic, morphological and phenotypic variation. Intensive research ef- forts aimed at enhancing our understanding of anti-Candida immunity have identi ed multiple immune cells involved in fungal sensing and defense. Adaptive immunity against Candida is complex and triggers a combination of T helper (Th1), Th2 and Th17 e ector cells engaged in the defense response against systemic or mucosal infections. IFNγ production by Th1 cells increased the fungicidal activity of mac- rophages and neutrophils. IL-17 and IL-22 shaped Th17 responses and also induced the activation and recruitment of neutrophils. Th17 responses occur mainly throughout mucosal infections. |
| Technique | Analytic |
| Analysis Method | Flow Cytometry Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Flow Cytometry Analysis |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
