| DB ID | MyCo_3352 |
| Title | Protection against rat vaginal candidiasis by adoptive transfer of vaginal B lymphocytes |
| Year | 2010 |
| PMID | 20402794 |
| Fungal Diseases involved | Vulvovaginal candidiasis |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | None |
| Site of Infection | Vagina |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted tissue |
| Host Group | Animal |
| Host Common name | Rat |
| Host Scientific name | Rattus norvegicus |
| Biomarker Name | IL-2 |
| Biomarker Full Name | Interleukin-2 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Italy |
| Cohort | Oophorectomized female Wistar rats (80–100 g; Charles River Breeding Laboratories, Calco, Italy) were used throughout this study. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Vulvovaginal candidiasis, mostly caused by Candida albi-cans, is a common mucosal infection affecting many wo- men, with some of them affected by recurrent and often intractable forms of the disease. Antifungal therapy is effective for individual attacks but may be unable to prevent recurrences. There is a consensus that local rather than systemic immunity is critical for anti-Candida defense at the vaginal mucosa; however, there are remarkable discrepancies concerning the role played by local humoral and cellular factors that have been suggested to confer protection. |
| Technique | Analytic |
| Analysis Method | Flow Cytometry Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Flow Cytometry Analysis, ELISA Based Dot immunobinding assay |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
