| DB ID | MyCo_3348 |
| Title | Role of neutrophils in IL-17-dependent immunity to mucosal candidiasis |
| Year | 2014 |
| PMID | 24442441 |
| Fungal Diseases involved | Oropharyngeal candidiasis |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | Protocols were approved by the University of Pittsburgh Institutional Animal Care and Use Committee and adhered to guidelines in the Guide for the Care and Use of Laboratory Animals of the NIH. |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Biopsy |
| Sample source | Homogenized Tongue tissue |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | IL-17 |
| Biomarker Full Name | Interleukin-17 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Pittsburgh, PA |
| Cohort | IL-23p19−/− mice were provided by Genentech (South San Francisco, CA) and IL 17RA−/− mice by Amgen (Seattle, WA) and bred in-house. All other mice were from The Jackson Laboratory (Bar Habor, ME) on the C57BL/6 background unless noted |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Oropharyngeal candidiasis (OPC, thrush) is an opportunistic mucosal infection caused by the commensal fungus Candida albicans. C. albicans causes disease when exposure is combined with host susceptibility through immunodeficiency or a breach in normal barriers. A range of primary and secondary immunodeficiency syndromes are associated with susceptibility to OPC, including the primary immunodeficiency Hyper-IgE syndrome and a family of genetic diseases leading to chronic mucocutaneous candidiasis (CMC). Secondary immunodeficiencies are now the most common predisposing factor for mucosal Candida disease. OPC is well described in patients with human immunodeficiency virus (HIV) and is considered an AIDS-defining illness. Cancer chemotherapy, immunosuppression for transplant recipients, renal failure and high-dose corticosteroids increase the risk of candidiasis. |
| Technique | Analytic |
| Analysis Method | Flow Cytometry Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Flow Cytometry Analysis, qRT-PCR |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
