| DB ID | MyCo_3313 |
| Title | TREM1 regulates antifungal immune responses in invasive pulmonary aspergillosis |
| Year | 2021 |
| PMID | 33525982 |
| Fungal Diseases involved | Invasive pulmonary aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | fumigatus |
| Organism | Aspergillus fumigatus |
| Ethical Statement | Study approval was obtained for the use of human samples from the Ethics Subcommittee for Life and Health Sciences of the University of Minho, Portugal (protocols 125/014 and 126/014), and the Ethics Committee of the University Hospitals of Leuven, Belgium. Murine infections were performed in dedicated facilities of the National Center for Microbiology. The project was ethically approved by the Animal Welfare Committee of the Instituto de Salud Carlos III and performed under the approved Project License PROEX 324/16. |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Bronchoalveolar lavage fluid (BALF) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | TREM1 |
| Biomarker Full Name | Triggering receptor expressed on myeloid cells 1 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Belgium |
| Cohort | Bronchoalveolar lavage (BAL) samples were collected from hospitalized adult patients (≥18 years of age) during routine diagnostic workup following suspicion of infection at the Leuven University Hospitals, Leuven, Belgium. |
| Cohort No. | None |
| Age Group | ≥18 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive Pulmonary Aspergillosis (IPA) is a severe disease that can develop in immunocompromised hosts, such as individuals with neutropenia, those treated for hematological malignancies, and recipients of hematopoietic stem cell (HSCT) or solid organ transplantation (SOT). Despite improvements in antifungal therapy and the availability of better diagnostic tools, the detection, definitive diagnosis, and treatment of this disease remains challenging. |
| Technique | Analytic |
| Analysis Method | Flow Cytometry Analysis |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | Flow Cytometry Analysis, qRT-PCR |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
