| DB ID | MyCo_3264 |
| Title | Preliminary evaluation of whole-blood gamma interferon release for clinical assessment of cellular immunity in patients with active coccidioidomycosis |
| Year | 2005 |
| PMID | 15939743 |
| Fungal Diseases involved | Coccidioidomycosis |
| Associated Medical Condition | None |
| Genus | Coccidioides |
| Species | spp. |
| Organism | Coccidioides spp. |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | IFNγ |
| Biomarker Full Name | Interferon gamma |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | Patients referred to the Coccidioidomycosis Clinic of the Southern Arizona Veterans Affairs Medical Center who had agreed to be part of a prospective study of coccidioidomycosis served as the subjects for this study. |
| Cohort No. | 69 |
| Age Group | >18 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Coccidioidomycosis is a fungal infection endemic in regions of the western United States, in northern Mexico, and in focal areas of Central and South America. Recently, the num- ber of symptomatic cases in the United States has been in- creasing. Like tuberculosis, coccidioidomycosis is a granulomatous disease, and the expression of delayed-type hy- persensitivity (DTH) has both epidemiologic and prognostic importance. Unfortunately, the most common clinical tools to measure coccidioidal cellular immunity, the coccidioidin and spherulin skin tests, are not currently available in the United States. |
| Technique | ELISA + Assay |
| Analysis Method | FDA approved-QuantiFERON-CMI assay |
| ELISA kits | None |
| Assay Data | FDA approved-QuantiFERON-CMI assay (Cellistis Lim- ited, Victoria, Australia) |
| Validation Techniques used | FDA approved-QuantiFERON-CMI assay |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
