MycoBiomDB – Record Details (MyCo_3245)

Biomarker Record Details

Database ID: MyCo_3245
DB IDMyCo_3245
TitleAssociation between circulating DNA, serum (1->3)-β-D-glucan, and pulmonary fungal burden in Pneumocystis pneumonia
Year2012
PMID22523258
Fungal Diseases involvedPneumocystis pneumonia
Associated Medical ConditionNone
GenusPneumocystis
Speciesjirovecii
OrganismPneumocystis jirovecii
Ethical StatementThis study was approved by the Henri Mondor Hospital Ethics Review Committee (IMCJ- H20-569).
Site of InfectionNone
Opportunistic invasiveNone
Sample typeBody fluid
Sample sourceSerum
Host GroupHuman
Host Common nameHuman
Host Scientific nameHomo sapiens
Biomarker NameBDG
Biomarker Full Name1-3-beta-D-Glucan
Biomarker TypeDiagnostic
BiomoleculeProtein
Geographical LocationFrance
CohortAs part of a retrospective single-center, hospital-based cohort study involving all patients undergoing BAL to investigate the cause of pneumonia A total of 70 serum samples were collected from 63 patients, with 1 patient having 4 BALs and 4 patients 2 BALs (median intervals, 16 days; range, 15–318).
Cohort No.63
Age GroupNone
P ValueNone
SensitivityNone
SpecificityNone
Positive Predictive ValueNone
MICNone
Fold ChangeNone
PathwayNone
Disease Introduction MechanismNone
TechniqueELISA
Analysis MethodFDA Approved-Fungitell assay
ELISA kitsNone
Assay DataFDA- Fungitell®, Cape Cod International, Inc.; Falmounth, MA, USA
Validation Techniques usedFDA Approved-Fungitell assay, qRT-PCR
Up Regulation Down RegulationIncrease
Sequence DataNone
External LinkNone