| DB ID | MyCo_3242 |
| Title | Serum (1-->3) beta-D-glucan as a noninvasive adjunct marker for the diagnosis of Pneumocystis pneumonia in patients with AIDS |
| Year | 2009 |
| PMID | 19725788 |
| Fungal Diseases involved | Pneumocystis pneumonia |
| Associated Medical Condition | AIDS |
| Genus | Pneumocystis |
| Species | jirovecii |
| Organism | Pneumocystis jirovecii |
| Ethical Statement | This study was approved by the Ethics Review Committee of the hospital (IMCJ-H20-569), International Medical Center of Japan, Tokyo, Japan. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | BDG |
| Biomarker Full Name | 1-3-beta-D-Glucan |
| Biomarker Type | Negative |
| Biomolecule | Protein |
| Geographical Location | Japan |
| Cohort | Here evaluated data from 111 consecutive HIV-1– infected patients with PCP at the International Medical Center of Japan, an 885-bed tertiary care hospital in Tokyo, from April 1997 through July 2007. |
| Cohort No. | 111 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Pneumocystis pneumonia (PCP) is associated with significant morbidity and mortality in patients with human immnuode- ficiency virus type 1 (HIV-1) infection [1, 2]. PCP is usually diagnosed microscopically by identifying Pneumocystis jirovecii in bronchoalveolar lavage fluid (BALF) or bronchoscopically obtained lung tissue [3]. Bronchoscopy, however, is inva sive, especially in patients with hypoxemia associated with PCP. Therefore, a minimally invasive method is desirable for diagnosis. |
| Technique | ELISA |
| Analysis Method | FDA Approved-Fungitell assay |
| ELISA kits | None |
| Assay Data | FDA- Fungitell®, Cape Cod International, Inc.; Falmounth, MA, USA |
| Validation Techniques used | FDA Approved-Fungitell assay |
| Up Regulation Down Regulation | Negative |
| Sequence Data | None |
| External Link | None |
