| DB ID | MyCo_3228 |
| Title | Prognostic value of serial (1,3)-β-D-glucan measurements in ICU patients with invasive candidiasis |
| Year | 2024 |
| PMID | 38997712 |
| Fungal Diseases involved | Invasive candidiasis |
| Associated Medical Condition | ICU patients |
| Genus | Candida |
| Species | glabrata |
| Organism | Candida glabrata |
| Ethical Statement | The study received approval from the local ethic committee (UCSC1123/11); patients’ informed consent was waived due to the observational design. |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | BDG |
| Biomarker Full Name | 1-3-beta-D-Glucan |
| Biomarker Type | Prognostic |
| Biomolecule | Protein |
| Geographical Location | Italy |
| Cohort | In the study population of 103 patients (age 47 [35–62] years, SAPS II score 67 [52–77]) 68 bloodstream and 35 intrabdominal infections were recorded. |
| Cohort No. | 103 |
| Age Group | 35–62 |
| P Value | None |
| Sensitivity | None |
| Specificity | 1 |
| Positive Predictive Value | 1 |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive candidiasis (IC) remains the most common seri- ous fungal infection in intensive care unit (ICU) patients and it is still associated with high mortality rates. Prompt diagnosis and appropriate therapy are of upmost importance in this setting; however, in almost half cases blood/tissue cultures could result negative and the iden- tification of pathogens as well as their antifungal suscep- tibility definition could take some days. |
| Technique | ELISA |
| Analysis Method | FDA Approved-Fungitell assay |
| ELISA kits | None |
| Assay Data | FDA- Fungitell®, Cape Cod International, Inc.; Falmounth, MA, USA |
| Validation Techniques used | FDA Approved-Fungitell assay |
| Up Regulation Down Regulation | Decrease |
| Sequence Data | None |
| External Link | None |
