MycoBiomDB – Record Details (MyCo_3209)

Biomarker Record Details

Database ID: MyCo_3209
DB IDMyCo_3209
TitlePerformance of Candida albicans germ tube antibodies (CAGTA) and its association with (1 → 3)-β-D-glucan (BDG) for diagnosis of invasive candidiasis (IC)
Year2018
PMID30098849
Fungal Diseases involvedInvasive candidiasis
Associated Medical ConditionNone
GenusCandida
Speciesglabrata
OrganismCandida glabrata
Ethical StatementAll procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional re-search committee (n. 59/17) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Site of InfectionNone
Opportunistic invasiveNone
Sample typeBody fluid
Sample sourceSerum
Host GroupHuman
Host Common nameHuman
Host Scientific nameHomo sapiens
Biomarker NameBDG
Biomarker Full Name1-3-beta-D-Glucan
Biomarker TypeDiagnostic
BiomoleculeProtein
Geographical LocationItalia
CohortHere retrospectively analyzed the presence of CAGTA on−80 °C stored serum samples, where the level of BDG had been previously assessed in a prospective study conducted in the Azienda Ospedaliero–Universitaria Policlinic of Modena. In particular, here selected 29 samples from proven IC episodes and 28 from non-IC cases.
Cohort No.57
Age GroupNone
P ValueNone
Sensitivity0.9
Specificity0.75
Positive Predictive ValueNone
MICNone
Fold ChangeNone
PathwayNone
Disease Introduction MechanismNone
TechniqueELISA
Analysis MethodFDA Approved-Fungitell assay
ELISA kitsNone
Assay DataNone
Validation Techniques usedFDA Approved-Fungitell assay, Immunofluorescence assay
Up Regulation Down RegulationPositive
Sequence DataNone
External LinkNone