| DB ID | MyCo_3130 |
| Title | Combined use of serum (1,3)-β-D-glucan and procalcitonin for the early differential diagnosis between candidaemia and bacteraemia in intensive care units |
| Year | 2017 |
| PMID | 28693606 |
| Fungal Diseases involved | Candidemia |
| Associated Medical Condition | ICU Patients |
| Genus | Candida |
| Species | glabrata |
| Organism | Candida glabrata |
| Ethical Statement | Specific informed consent for this study was not necessary because of the retrospective nature of the analyses. The study was approved by the Ethics Committee of the coordinating centre (Regional Ethics Committee of Liguria Region, N. Registro CER Liguria: 270REG2016). |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | PCT + BDG |
| Biomarker Full Name | Procalcitonin + 1-3-beta-D-Glucan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Italy |
| Cohort | From June 2014 to December 2015, all adult patients admitted to the ICU who had a culture-proven candidaemia or bacteraemia, as well as BDG and PCT measured closely to the time of the index culture, were included in the study. One hundred and sixty-six patients were included, 73 with candidaemia (44%) and 93 with bacteraemia (56%). |
| Cohort No. | 166 |
| Age Group | 52-76 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | ELISA + Immunological assay |
| Analysis Method | FDA approved Fungitell assay+sandwich chemiluminescence immunoassay |
| ELISA kits | sandwich chemiluminescence immunoassay (CLIA; Li- aison® BRAHMS® PCT II GEN, DiaSorin, Saluggia, Italy) |
| Assay Data | FDA- Fungitell®, Cape Cod International, Inc.; Falmounth, MA, USA |
| Validation Techniques used | FDA approved Fungitell assay+sandwich chemiluminescence immunoassay |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
