| DB ID | MyCo_3089 |
| Title | Performance of a Quantitative PCR-Based Assay and Beta-d-Glucan Detection for Diagnosis of Invasive Candidiasis in Very-Low-Birth-Weight Preterm Neonatal Patients (CANDINEO Study) |
| Year | 2017 |
| PMID | 28659321 |
| Fungal Diseases involved | Invasive candidiasis |
| Associated Medical Condition | Very-Low-Birth-Weight Preterm Neonatal Patients (CANDINEO Study) |
| Genus | Candida |
| Species | spp. |
| Organism | Candida spp. |
| Ethical Statement | The multicenter nationwide study was undertaken in Spain and was registered and approved by the Clinical Trial and Ethics Committee of the University Hospital 12 de Octubre, Madrid, Spain (reference number CEIC 10/244). |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | BDG |
| Biomarker Full Name | 1-3-beta-D-Glucan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Spain |
| Cohort | Seventeen centers participated in the study, and the number of episodes analyzed was 159. A total of 9 episodes of IC from 9 patients (7 confirmed and 2 probable) and 150 episodes of suspected sepsis from 117 controls were identified. |
| Cohort No. | 9 Patients and 117 control |
| Age Group | 0-44 |
| P Value | p< 0.01 |
| Sensitivity | 0.75 |
| Specificity | 0.646 |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Candida species infection is one of the leading causes of death in very-low-birth- weight (VLWB; 1,250 g) preterm infants. Candida spp. represent the third- most-common pathogens isolated from bloodstream infections of preterm infants in neonatal intensive care units (NICU) and the fourth-most-common pathogens in pedi- atric intensive care unit patients. Candida albicans is the most common fungal species infecting neonates, followed by Candida parapsilosis. In addition, Candida species infections tend to disseminate as invasive candidiasis (IC) in VLWB neonates more frequently than in adults or older children throughout all organ systems, includ- ing the central nervous system (CNS), leading to a high mortality rate and neurocog- nitive impairment in survivors. The successful management of these patients requires the early detection and identification of the infectious agent to guide the initiation of appropriate antifungal therapy. |
| Technique | ELISA |
| Analysis Method | FDA approved Fungitell assay |
| ELISA kits | None |
| Assay Data | Fungitell assay (Fontlab Ltd., Barcelona, Spain) |
| Validation Techniques used | FDA approved Fungitell assay |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
