| DB ID | MyCo_2973 |
| Title | High prevalence of peribronchial focal lesions of airway invasive aspergillosis in hematological cancer patients with prolonged neutropenia |
| Year | 2020 |
| PMID | 32462888 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | Hematological cancer patients with prolonged neutropenia |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | GM |
| Biomarker Full Name | Galactomannan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Switzerland |
| Cohort | 35 patients were identified. |
| Cohort No. | 35 |
| Age Group | 22–79 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive pulmonary aspergillosis (IPA) is a life-¬ threatening infection affecting hematological cancer patients with chemotherapy-¬ induced neutropenia. CT-¬ scan imaging plays a critical role in IPA diagnosis. In neutropenic patients, well-¬ circumscribed lesions with or without the halo sign are highly suggestive findings of IPA, according to European Organization for Research and Treatment of Cancer and Mycoses Study Group (EORTC/MSG) diag- nostic criteria. Conversely, peribronchial consolidations are classically described in airway invasive aspergillosis in non-¬ hematological cancer patients. |
| Technique | ELISA |
| Analysis Method | FDA Approved -Platelia Aspergillus ELISA |
| ELISA kits | ELISA Kit- Platelia Aspergillus (Platelia Aspergillus EIA; Bio-Rad Laboratories, Redmond, WA, USA) |
| Assay Data | None |
| Validation Techniques used | FDA Approved -Platelia Aspergillus ELISA |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
