| DB ID | MyCo_2970 |
| Title | Early serum galactomannan trend as a predictor of outcome of invasive aspergillosis |
| Year | 2012 |
| PMID | 22553232 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | The protocol was approved by the appropriate institutional review boards (Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands), and written informed consent was obtained from all patients. |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | GM |
| Biomarker Full Name | Galactomannan |
| Biomarker Type | Predictive |
| Biomolecule | Protein |
| Geographical Location | The Netherlands |
| Cohort | Two hundred two patients had a diagnosis of proven, probable, or possible invasive aspergillosis, with at least two serum GMI results available for analysis. |
| Cohort No. | 202 |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive aspergillosis (IA) remains the most common mold in- fection, causing significant mortality and morbidity in immu- nocompromised patients. Securing a firm diagnosis of the disease and monitoring the response to treatment are difficult, as the patient may not exhibit reliable symptoms and signs in the presence of neutropenia and immune-modulating drugs, such as corticosteroids. Over the years, the diagnostic capability for the detection of IA has improved through the use of Aspergillus galac- tomannan (GM) antigen. |
| Technique | ELISA |
| Analysis Method | FDA Approved -Platelia Aspergillus ELISA |
| ELISA kits | ELISA Kit- Platelia Aspergillus ((Platelia Aspergillus EIA; Bio-Rad Laboratories, Marne-la-Coquette, France) |
| Assay Data | None |
| Validation Techniques used | FDA Approved -Platelia Aspergillus ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
