| DB ID | MyCo_2948 |
| Title | Effect of volume of instillate on the diagnostic utility of bronchoalveolar lavage galactomannan in patients with suspected chronic pulmonary aspergillosis-A pilot study |
| Year | 2024 |
| PMID | 38282361 |
| Fungal Diseases involved | Chronic pulmonary aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | Ethics approval for the study was obtained from the Institute Ethics Committee (IEC) (IECPG- |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Bronchoalveolar lavage fluid (BALF) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | GM |
| Biomarker Full Name | Galactomannan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | India |
| Cohort | The study population included consecutive adults (between 18 and 60 years of age) who presented to the outpatient department and Chest Clinic of the Department of Medicine, AIIMS, New Delhi for evaluation of chronic respiratory symptoms (>3 months). A total of 69 patients were screened and 50 consecutive patients with suspected CPA, who underwent bronchoscopy and bronchoalveolar lavage (BAL), were enrolled in the study. |
| Cohort No. | 69 |
| Age Group | 18-60 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Chronic pulmonary aspergillosis (CPA) refers to a conglomerate of entities having characteristic clinic-¬ radio-¬ serological features, occur- ring typically in patients with pre-¬ existing structural lung diseases. The different conditions included in this umbrella term are chronic cavitary pulmonary aspergillosis, chronic fibrosing pulmonary aspergillosis, simple aspergilloma, subacute invasive aspergillosis and Aspergillus nodule. |
| Technique | ELISA |
| Analysis Method | FDA Approved -Platelia Aspergillus Ag ELISA |
| ELISA kits | ELISA Kit- Platelia Aspergillus (Platelia Aspergillus EIA; Bio- Rad Laboratories, Inc.,USA). |
| Assay Data | None |
| Validation Techniques used | FDA Approved -Platelia Aspergillus Ag ELISA |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
