| DB ID | MyCo_2742 |
| Title | TREM-1 promoted apoptosis and inhibited autophagy in LPS-treated HK-2 cells through the NF-κB pathway |
| Year | 2021 |
| PMID | 33390769 |
| Fungal Diseases involved | Sepsis-associated acute kidney injury (SA-AKI) |
| Associated Medical Condition | None |
| Genus | None |
| Species | None |
| Organism | None |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Biopsy |
| Sample source | Lipopolysaccharide (LPS) treated human kidney-2 (HK-2) cell line |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | Bcl-2 |
| Biomarker Full Name | B-cell lymphoma-2 |
| Biomarker Type | Prognostic |
| Biomolecule | Gene |
| Geographical Location | China |
| Cohort | None |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Sepsis is the leading cause of death in patients admitted to the intensive care unit, and death from sepsis is caused by a deleterious immune response to infection. Severe sepsis is associated with multiorgan dysfunction, but the mechanisms leading to this dysfunction remain unclear. The kidney is the organ most commonly affected by sepsis, leading to sepsis-associated acute kidney injury (SA-AKI). Acute kidney injury (AKI) develops in up to 60% of patients with sepsis, and up to 50% of patients with AKI have sepsis. |
| Technique | ELISA |
| Analysis Method | ELISA Based nuclear factor-κB (NF-κB) signaling pathway |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA, qRT-PCR, Western Blot |
| Up Regulation Down Regulation | Down regulated |
| Sequence Data | None |
| External Link | None |
