| DB ID | MyCo_2740 |
| Title | Immune Resolution Dilemma: Host Antimicrobial Factor S100A8/A9 Modulates Inflammatory Collateral Tissue Damage During Disseminated Fungal Peritonitis |
| Year | 2021 |
| PMID | 33717058 |
| Fungal Diseases involved | Intra-abdominal candidiasis |
| Associated Medical Condition | None |
| Genus | Candida |
| Species | albicans |
| Organism | Candida albicans |
| Ethical Statement | Animal experiments and isolation of primary cells were carried out following the recommendations in the Guide for the Care and Use of Laboratory Animals, conformed to Swedish animal protection laws and applicable guidelines (djurskyddslagen 1988:534; djurskyddsförordningen 1988:539; djurskyddsmyndigheten DFS 2004:4) in a protocol approved by the local Ethical Committee (Umeå djurförsöksetiska nämnd, permit numbers A12-13, A80-14, A79-14, A21-2020). Written informed consent was obtained from the owners for the participation of their animals in this study. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Biopsy |
| Sample source | Extracted tissue |
| Host Group | Animal |
| Host Common name | Mice |
| Host Scientific name | Mus musculus |
| Biomarker Name | S100A8/A9 (calprotectin) |
| Biomarker Full Name | S100A8/A9 (calprotectin) |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Germany |
| Cohort | All mice were maintained at Umeå Centre for Comparative Biology (UCCB), Umeå University, Umeå, Sweden. Inbred C57BL/6 mice served as WT strain and inbred S100A9-/- strain, which was obtained from University of Münster, with the same genetic background as C57BL/6 served as S100A8/A9-deficient strain. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | ELISA |
| Analysis Method | ELISA Based Myeloperoxidase Activity Assay |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | ELISA Based Myeloperoxidase Activity Assay |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
