| DB ID | MyCo_2730 |
| Title | Synovial fluid neutrophil extracellular traps could improve the diagnosis of periprosthetic joint infection |
| Year | 2023 |
| PMID | 36718647 |
| Fungal Diseases involved | Fungal periprosthetic joint infection |
| Associated Medical Condition | None |
| Genus | None |
| Species | None |
| Organism | None |
| Ethical Statement | This study was approved by an Ethics Committee of First Affiliated Hospital, Fujian Medical University, and enrolled patients who received revision surgery due to aseptic failure (AF) or PJI in our centre from 2013 to 2021. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Synovial fluid |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | SF- |
| Biomarker Full Name | Synovial fluid neutrophil extracellular trap |
| Biomarker Type | Diagnostic |
| Biomolecule | None |
| Geographical Location | China |
| Cohort | In a single health centre, patients with suspected PJI were enrolled from January 2013 to December 2021. (n=46) and patients who were diagnosed as AF were selected as controls. (n=28). |
| Cohort No. | 46 Patients and 28 control |
| Age Group | 62.32-65.28 |
| P Value | None |
| Sensitivity | 0.9348 |
| Specificity | 0.9643 |
| Positive Predictive Value | 0.9773 |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Periprosthetic joint infection (PJI) is a devastating compli- cation after joint arthroplasty; the incidence rate is about 1% to 2%. Since there are growing numbers of patients who receive arthroplasty surgery, the number of PJIs is increasing year by year, posing a challenge to orthopaedic doctors. Therefore, how to diagnose PJI precisely and treat it well is an important issue, which remains to be addressed. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | NETs enzyme linked immuno-sorbent assay (ELISA) kit (Hu00596, BOSK biology engi-neering, China) |
| Assay Data | None |
| Validation Techniques used | Synovial fluid NET test |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
