| DB ID | MyCo_2714 |
| Title | The pitfall in evaluating several serological markers of Pneumocystis carinii pneumonia in a neutropenic patient |
| Year | 2000 |
| PMID | 10939542 |
| Fungal Diseases involved | Pneumocystis carinii pneumonia |
| Associated Medical Condition | None |
| Genus | Pneumocystis |
| Species | carinii |
| Organism | Pneumocystis carinii |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | CK19 |
| Biomarker Full Name | Cytokeratin 19 fragment |
| Biomarker Type | Negative |
| Biomolecule | Protein |
| Geographical Location | Japan |
| Cohort | A 72-year-old womanwho had received treatment of combined chemotherapy for a malignant lymphoma (non-Hodgkin's lymphoma, diffuse, medium, B-cell) for 1 year, was admitted to KagawaMedical University to receive a combination chemotherapy [vincristine 1 mg/body (day 1, 8, 15), cyclophosphamide 500 mg/body (day 1, 8, 15), methotrexate 25 mg/body (day 1, 8, 15), and oral prednisolone. |
| Cohort No. | 1 |
| Age Group | 72 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Peumocystis carinii pneumonia (PCP) is a life-threatening opportunistic infection associated with suppressed cellular immunity in patients with acquired immunodeficiency syndrome (AIDS) or patients receiving anti-cancer and immuno- suppressive therapy. Pulmonary infection with Pneumocystis carinii (P. carinii) is associated with histologic findings of interstitial pneumonitis and sometimes irreversible fibrotic changes. It has been reported that the severity of HIV-associated PCP is related to the percentage of neutrophilic granulocytes in the bronchoalveolar lavage (BAL) fluid at the time of diagnosis. This suggests that inflammatory activity is central in the pathogenesis of PCP. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | PIIINP Radioimmunoassay Kit (Farmos Diagnostica, Oulu, Finland) , Sandwich immunoassay Kit; streptvidin-biotin technique (Enzymun-Test CYFRA21- 1 ; Boehringer Mannheim GmbH, Tutzing, Germany). |
| Assay Data | None |
| Validation Techniques used | Sandwich immunoassay |
| Up Regulation Down Regulation | Negative |
| Sequence Data | None |
| External Link | None |
