| DB ID | MyCo_2611 |
| Title | Effect of patient immunodeficiencies on the diagnostic performance of serological assays to detect Aspergillus-specific antibodies in chronic pulmonary aspergillosis |
| Year | 2021 |
| PMID | 33529993 |
| Fungal Diseases involved | Chronic pulmonary aspergillosis |
| Associated Medical Condition | None |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | MBL |
| Biomarker Full Name | Mannose-binding lectin |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | UK |
| Cohort | Here performed a retrospective review of secondary data obtained from 167 CPA patients identified at the National Aspergillosis Centre (NAC) (Manchester, UK). |
| Cohort No. | 167 Patients |
| Age Group | 32-87 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive aspergillosis occurs primarily in patients with profound, but sometimes temporary, immunodeficiency, in contrast to chronic pulmonary aspergillosis (CPA) which occurs in people with no discernible immunodeficiency state. Over the last few years, several subtle immune defects have been found in some, but not all, CPA patients including mannose binding lectin deficiency, poor encapsulated bacterial vaccine responses, low circulating T- and natural killer cells, and interleukin-12 and gamma interferon defects. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | Aspergillus fumigatus IgG ELISA (Bordier Affinity Products, Crissier, Switzerland) |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Decrease |
| Sequence Data | None |
| External Link | None |
