| DB ID | MyCo_2574 |
| Title | Improved Detection of Invasive Pulmonary Aspergillosis Arising during Leukemia Treatment Using a Panel of Host Response Proteins and Fungal Antigens |
| Year | 2015 |
| PMID | 26581097 |
| Fungal Diseases involved | Invasive pulmonary aspergillosis |
| Associated Medical Condition | Leukemia |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | This study was conducted by the Aspergillus Technology Consortium (AsTeC) under approval by the University of Florida Institutional Review Board (IRB) protocol 073–2008 and by th UTMB Clinical Proteomics Center (CPC) under approval from UTMB IRB No. 08–258. This study was compliant with all applicable federal regulations governing the protection of human subjects. Most subjects were adults who provided written, informed consent prior to participa-tion in the study. Subjects under the age of 18 provided either written informed consent or assent with parent/guardian providing written consent. |
| Site of Infection | None |
| Opportunistic invasive | Opportunistic |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | GM |
| Biomarker Full Name | Galactomannan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | USA |
| Cohort | Three patient populations at high risk for IPA were enrolled by informed consent or assent at the start of their transplant or chemotherapy treatment at the 3 AsTeC collection sites. N=85, N=37, N=57. |
| Cohort No. | 8,53,757 |
| Age Group | 52.66 ± 13.59, 52.84 ± 15.12, 52.54 ± 14.4 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | sandwich ELISA (Bioplex, Bio-Rad, Hercules, CA), Platelia Aspergillus enzyme immunoassay (EIA) (Bio-Rad Laboratories, Redmond, WA) |
| Assay Data | None |
| Validation Techniques used | ELISA, GM-Platelia™ Aspergillus Ag ELISA, SID-SRM-MS assay, FDA approved Fungitell assay |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
