| DB ID | MyCo_2570 |
| Title | Combined real-time PCR and galactomannan surveillance improves diagnosis of invasive aspergillosis in high risk patients with haematological malignancies |
| Year | 2013 |
| PMID | 23614624 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | Hematological malignancies |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | Prior approval for the study was obtained from the St James’s Hospital (SJH) Research Ethics committee and the Ethical Committee of the University Hospital of Wuerzburg (UKW). |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | GM |
| Biomarker Full Name | Galactomannan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Ireland |
| Cohort | Patients undergoing remission-induction chemotherapy for acute leukaemia, lymphoma, or myeloma, autologous or allogeneic bone marrow or stem cell transplant (allo-SCT), were eligible for inclusion. Over the course of the study 146 patients were recruited from SJH and 132 from UKW. |
| Cohort No. | 146 |
| Age Group | None |
| P Value | None |
| Sensitivity | 0.6-0.48% |
| Specificity | 0.92-0.89% |
| Positive Predictive Value | 0.47-0.61% |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive aspergillosis (IA) has become the leading cause of invasive fungal disease (IFD) following intensive remission- induction chemotherapy, or haematopoietic stem cell transplantation for acute leukaemia and lymphoproliferative disorders. Aspergillus fumigatus is the species most commonly isolated from cases of IA. A major factor in deter- mining the poor outcome of this disease is delay in detection of Aspergillus infection and diagnosis of disease, and conse- quent sub-optimal therapy. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | GM-Platelia™ Aspergillus Ag ELISA, PCR |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
