| DB ID | MyCo_2567 |
| Title | Performance of serum biomarkers for the early detection of invasive aspergillosis in febrile, neutropenic patients: a multi-state model |
| Year | 2013 |
| PMID | 23799048 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | Febrile, Neutropenic Patients |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | The clinical trial and th present study had been approved by the ethics committee of Henri Mondor Teaching Hospital. |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | GM |
| Biomarker Full Name | Galactomannan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | France |
| Cohort | The adult patients evaluated in this study had been enrolled in a prospective, randomized, open-label, non-inferiority trial conducted from April 2003 to February 2006 in 13 French teaching hospitals (ClinicalTrials.gov Identifier: NCT001190463). Of 293 patients enrolled in the trial, we selected all 185 (63%) febrile, neutropenic patients treated with chemotherapy for acute myeloid leukemia to constitute a homogeneous group at high risk of developing invasive aspergillosis. |
| Cohort No. | 185 |
| Age Group | 54 |
| P Value | p=.53 |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | None |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | Platelia™ Aspergillus Ag Kit (BioRad, Hercules, CA, USA) |
| Assay Data | FDA- Fungitell®, Cape Cod International, Inc.; Falmounth, MA, USA |
| Validation Techniques used | GM-Platelia™ Aspergillus Ag ELISA, FDA approved Fungitell assay, qRT-PCR Multi-state model |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
