| DB ID | MyCo_2565 |
| Title | Comparison of serum and bronchoalveolar lavage galactomannan in diagnosing invasive aspergillosis in solid-organ transplant recipients |
| Year | 2012 |
| PMID | 22631066 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | Solid-Organ Transplant Recipients |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | All protocols were approved by the ethics committee of the institution before the study began, and the protocols conformed to the ethical guidelines of the 1975 Helsinki Declaration. |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Bronchoalveolar lavage fluid (BALF) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | GM |
| Biomarker Full Name | Galactomannan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Iran |
| Cohort | This study took place from January 2009 to January 2010 at the lung transplant center of Massih Daneshvari Hospital, which is the primary hospital for heart and lung transplants in Iran. Seventeen patients were included (lung, 15; heart, 1; heart-lung, 1). Probable or definite invasive aspergillosis was diagnosed in 9 patients. |
| Cohort No. | 17 |
| Age Group | None |
| P Value | None |
| Sensitivity | 1 |
| Specificity | 1 |
| Positive Predictive Value | 1 |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive aspergillosis of the lung is a major cause of morbidity and mortality in immunocompromised patients. Invasive aspergillosis occurs in 5% to 15% of patients with a solid-organ transplant. The highest risk is with lung transplant recipients owing to colonization of the airways with aspergillus spp. Despite advances in treatment, mortality remains high (58% to 74%). Therefore, rapid diagnosis and timely treatment may decrease mortality. Routine diagnostic measures such as smear and culture for fungi, radiology, and clinical symptoms have low sensitivity and specificity. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | double- sandwich enzyme-linked immunosorbent assay (platelia aspergillus; Bio Rad, Marnes, La Coquette, France). |
| Assay Data | None |
| Validation Techniques used | GM-Platelia™ Aspergillus Ag ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
