| DB ID | MyCo_2561 |
| Title | Clinical impact of enhanced diagnosis of invasive fungal disease in high-risk haematology and stem cell transplant patients |
| Year | 2008 |
| PMID | 19103864 |
| Fungal Diseases involved | Invasive fungal infection |
| Associated Medical Condition | Haematology and stem cell transplant patients |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | GM |
| Biomarker Full Name | Galactomannan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | UK |
| Cohort | Between 1 October 2005 and 31 March 2006 (test period), haematology patients admitted to University Hospital of Wales who were at high risk of IFD were entered into a care pathway for neutropenic fever management. Over the 6- month testing period, 130 patients were screened. |
| Cohort No. | 130 |
| Age Group | 16–83 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | The burden of invasive fungal disease (IFD) con-tinues to increase as a result of improved medical intervention and supportive care. Diagnosis is suboptimal and problematic in patients with hae- matological malignancy and those undergoing stem cell transplantation (SCT). Mortality is high if diagnosis is delayed, and IFD may delay further chemotherapy leading to higher relapse rates. This has led to the practice of empiric antifungal treatment in patients with refractory fever, although there is no evidence that this reduces invasive fungal infection in patients or confers a survival benefit. Costs associated with this practice are considerable, and drug toxicities increase morbidity and mortality further. Even lipid amphotericin B preparations are associated with nephrotoxicity, which, if severe, prolongs hospital stay and increases risk of death. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | None |
| Assay Data | None |
| Validation Techniques used | GM-Platelia™ Aspergillus Ag ELISA, Aspergillus PCR, Candida PCR |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
