| DB ID | MyCo_2552 |
| Title | Comparison of Serum Galactomannan and 1,3-Beta-D-Glucan Determination for Early Detection of Invasive Pulmonary Aspergillosis in Critically Ill Patients with Hematological Malignancies and Septic Shock |
| Year | 2016 |
| PMID | 27142781 |
| Fungal Diseases involved | Invasive pulmonary aspergillosis |
| Associated Medical Condition | Critically Ill Patients with Hematological Malignancies and Septic Shock |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | This observational study was conducted at the medical ICU of the University Hospital Technische Universita ¨tMu ¨nchen, Germany. This observational study without any specific intervention was reviewed and approved by the ethics committee of our university hospital, and all data were processed anonymously. |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | GM |
| Biomarker Full Name | Galactomannan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Germany |
| Cohort | This observational study was conducted at the medical ICU of the University Hospital Technische Universita ¨t Mu ¨nchen, Germany. This observational study without any specific intervention was reviewed and approved by the ethics committee of our university hospital, and all data were processed anonymously. Need for informed consent was waived for this analysis. We analyzed the medical records of all patients (18 years and older) with respiratory failure and septic shock who were treated at the ICU between December 2014 and December 2015. Out of these 144 patients we identified 30 (11 %) patients with hematological malignancies who were included in this study. Both tests were performed initially after admission to the ICU. As a standard procedure every patient with suspected IPA receives computed tomography of the chest. For validation reasons Galactomannan was also performed in BAL. |
| Cohort No. | 30 |
| Age Group | None |
| P Value | None |
| Sensitivity | 0.3 |
| Specificity | 0.98 |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive pulmonary aspergillosis (IPA) remains a significant cause of morbidity and mortality in patients with hematological malignancies. Especially in critically ill patients with hematological malignancies, the incidence of IPA is continuously increasing, due to both pathologic and therapeutic reasons. Early identification of IPA is challenging, because of the patients’ complexity; moreover, accompanying signs and symptoms are nonspecific in most cases and may not be present until the disease is advanced or disseminated. |
| Technique | Immunological assay |
| Analysis Method | ELISA Based |
| ELISA kits | GM - ELISA Kit (Platelia Aspergillus; Bio-Rad, Mar- nes-la-Coquette, France) |
| Assay Data | None |
| Validation Techniques used | GM Platelia assay |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
