| DB ID | MyCo_2477 |
| Title | Detection of galactomannan in bronchoalveolar lavage of the intensive care unit patients at risk for invasive aspergillosis |
| Year | 2015 |
| PMID | 28680975 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | Intensive care unit patients |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | The Ethics Committee of Mazandaran University of Medical Sciences (code: 88-6-4) approved this research. |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Bronchoalveolar lavage fluid (BALF) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | GM |
| Biomarker Full Name | Galactomannan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Iran |
| Cohort | 43 Patients were included in the study. |
| Cohort No. | 43 |
| Age Group | None |
| P Value | None |
| Sensitivity | 0.73 |
| Specificity | 0.927 |
| Positive Predictive Value | 0.89 |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive aspergillosis (IA) is one of the most common life-threatening fungal infections that has emerged as an important cause of morbidity and mortality in immunocompromised patients that ranges from 70% to 90% in one year. IA is due to ubiquitous Aspergillus species that invade from the lungs into the adjacent organs if the immune system is compromised. Recently several reports have revealed a rising incidence of IA in critically ill patients admitted to the intensive care unit (ICU) in otherwise healthy individuals. The occurrence of IA in the ICU usually entails a poor prognosis, despite major recent improvements in the diagnosis and treatment of IA in patients with hematologic diseases. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | ELISA Kit- Platelia Aspergillus (Platelia Aspergillus EIA, Platelia Aspergillus; Bio-Rad, Edmonds, WA) |
| Assay Data | None |
| Validation Techniques used | FDA Approved -Platelia Aspergillus ELISA |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
