| DB ID | MyCo_2471 |
| Title | Diagnosis of invasive aspergillosis in lung transplant recipients by detection of galactomannan in the bronchoalveolar lavage fluid |
| Year | 2010 |
| PMID | 20548265 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | Lung Transplant Recipients |
| Genus | Aspergillus |
| Species | niger |
| Organism | Aspergillus niger |
| Ethical Statement | Independent ethical approval was obtained from the institutional review board, and consent was obtained from patients before samples were processed. Patients’ notes were reviewed to record variables such as demographic data, underlying diseases, presence of prior Aspergillus colonization, and type of transplant (single or double). |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Bronchoalveolar lavage fluid (BALF) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | GM |
| Biomarker Full Name | Galactomannan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | Herein, prospectively studied BAL fluid samples from 60 lung transplant patients to determine the optimal cutoff for BAL GM testing. |
| Cohort No. | 60 |
| Age Group | 10–72 |
| P Value | None |
| Sensitivity | 1 |
| Specificity | 0.904 |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive aspergillosis (IA) is an important disease in the context of lung transplantation, with an incidence ranging from 6% to 16%. It is estimated that 9% of all deaths after lung transplant procedures are attributed to IA. Several factors put these individuals at high risk to acquire IA. These include direct communication of the transplanted organ with air that carries Aspergillus conidia, ischemic injury of the re-spiratory tract, decrease in the mucociliary clearance, and im- paired alveolar macrophages action. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | ELISA Kit- Platelia Aspergillus (Platelia Aspergillus EIA, Bio-Rad, France). |
| Assay Data | None |
| Validation Techniques used | FDA Approved -Platelia Aspergillus ELISA |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
