| DB ID | MyCo_2466 |
| Title | Aspergillus galactomannan testing in patients with long-term neutropenia: implications for clinical management |
| Year | 2008 |
| PMID | 18227109 |
| Fungal Diseases involved | Invasive aspergillosis |
| Associated Medical Condition | Hematological malignancies and profound neutropenia |
| Genus | Aspergillus |
| Species | spp. |
| Organism | Aspergillus spp. |
| Ethical Statement | None |
| Site of Infection | None |
| Opportunistic invasive | Invasive |
| Sample type | Body fluid |
| Sample source | Bronchoalveolar lavage fluid (BALF) |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | GM |
| Biomarker Full Name | Galactomannan |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Germany |
| Cohort | Two hundred patients were recruited in the study. |
| Cohort No. | 200 |
| Age Group | 23–74 |
| P Value | None |
| Sensitivity | 1 |
| Specificity | 0.938 |
| Positive Predictive Value | 0.607 |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Invasive aspergillosis (IA) is a major cause of morbidity and mortality in patients with hematologic malignancies undergoing intensive cytotoxic therapy or hematopoietic stem- cell transplantation (HSCT). Due to the increasing use of high- dose chemotherapy and the application of immunosuppressive agents, such as antilymphocyte antibodies, the incidence of IA is currently rising up to 30% in some centers. Early diagnosis of IA is generally considered to be mandatory to increase survival. Clinical symptoms and radiological signs of IA, however, are mostly nonspecific and occur late in the course of the disease, making early clinical and radiological diagnosis almost impossible. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | ELISA Kit- Platelia Aspergillus (Platelia Aspergillus EIA, Bio-Rad). |
| Assay Data | None |
| Validation Techniques used | FDA Approved -Platelia Aspergillus ELISA |
| Up Regulation Down Regulation | Positive |
| Sequence Data | None |
| External Link | None |
