| DB ID | MyCo_2388 |
| Title | Serum cytokines and clinical features in patients with fever and thrombocytopenia syndrome |
| Year | 2019 |
| PMID | 30831067 |
| Fungal Diseases involved | Fungal infection |
| Associated Medical Condition | Fever and thrombocytopenia syndrome |
| Genus | None |
| Species | None |
| Organism | None |
| Ethical Statement | This study was approved by the Ethics Committee of Shantou University Medical College and informed consents were obtained from the patients. |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Serum |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | PA-IgG |
| Biomarker Full Name | Platelet Associated Immunoglobulin G |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | China |
| Cohort | During the period of January 2016 to June 2017, patients with unexplained fever (body temperature>37.6 °C) and thrombocytopenia (platelet count<100×10 9/l) were enrolled in our study. Patients with solid tumors, leukemia, liver disease, or upper and lower gastrointestinal or other traumatic bleeding were excluded. Ten healthy volunteers were selected as the controls. |
| Cohort No. | None |
| Age Group | None |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Fever and thrombocytopenia are frequent symptoms in patients with viral/ fungal/ bacterial infection. Severe fever with thrombocytopenia syndrome (SFTS), caused by a novel bunyavirus, was initially identified in 2009. SFTS produces a broad spectrum of clinical manifestations that range from acute self-limited febrile illness to severe disease, with a reported fatality rate varying between 12% and 30%. Due to its poor prognosis and higher mortality, SFTS has quickly become an emerging infectious disease that has aroused extensive surveillance in public health. Currently, SFTS, together with meningitis syndrome and respiratory syndrome, are the primary three syndromes that are monitored in clinic. Unlike other inflammatory disease, the etiology of fever and thrombocytopenia is quite complicated; thrombocytopenia may arise due to a lack of platelet production, retention of platelets (PLTs) in the spleen, platelet destruction, or increased use and dilution of PLTs. In clinic, most thrombocytopenia patients are diagnosed as primary immune thrombocytopenia (ITP) that is defined as a peripheral blood platelet count<100×109/l in the absence of any obvious cause of thrombocytopenia. Because the etiology of ITP is so complicated that physicians seldom relies on its etiology to formulate treatment plans, then, it is difficult to explain why some patients have poor therapeutic efficacy. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | Human platelet-associated IgG antibody (PA-IgG) ELISA kit (Shanghai Jingkang, China), Human Platelet Activating Factor ELISA Kit (Dakewe, China) and Human IL-6/IL-10/IL-17A/IL-12/23P40/IFN-γ precoated ELISA Kit (CUSABIO,China) |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
