| DB ID | MyCo_2370 |
| Title | 43 kDa Glycoprotein (gp43) from Paracoccidioides brasiliensis Induced IL-17A and PGE2 Production by Human Polymorphonuclear Neutrophils: Involvement of TLR2 and TLR4 |
| Year | 2019 |
| PMID | 31886295 |
| Fungal Diseases involved | Paracoccidioidomycosis |
| Associated Medical Condition | None |
| Genus | Paracoccidioides |
| Species | brasiliensis |
| Organism | Paracoccidioides brasiliensis |
| Ethical Statement | This study was approved by the Research Ethics Committee from Botucatu Medical School, São Paulo State University (UNESP) (CAAE number: 80098817.8.0000.5411). |
| Site of Infection | None |
| Opportunistic invasive | None |
| Sample type | Body fluid |
| Sample source | Blood |
| Host Group | Human |
| Host Common name | Human |
| Host Scientific name | Homo sapiens |
| Biomarker Name | Gp43 |
| Biomarker Full Name | Glycoprotein 43 |
| Biomarker Type | Diagnostic |
| Biomolecule | Protein |
| Geographical Location | Brazil |
| Cohort | Heparinized venous blood was obtained from 7 voluntary healthy women, with age ranging from 19 to 37 years-old, after signing informed consent forms. |
| Cohort No. | 7 |
| Age Group | 19-37 |
| P Value | None |
| Sensitivity | None |
| Specificity | None |
| Positive Predictive Value | None |
| MIC | None |
| Fold Change | None |
| Pathway | None |
| Disease Introduction Mechanism | Paracoccidioidomycosis (PCM) is a systemic granulomatous disease prevalent in Latin America. The etiological agents belong to the Paracoccidioides gender of thermodimorphic fungi, among which Paracoccidioides brasiliensis is the most studied species. PCM infection initiates through the inhalation of environmental mycelium propagules that reach the pulmonary alveoli, where they can only survive upon transformation into yeasts, a process mediated by the body’s temperature. Disease establishment, progression, and severity depend both on fungi virulence factors as well as the host’s immunological response. |
| Technique | ELISA |
| Analysis Method | ELISA Based |
| ELISA kits | ELISA Sets (BD OptEIA™, BD, San Diego, CA, USA), DuoSet ELISA (R&D Systems, Minneapolis, MN, USA), ELISA kit from Cayman Chemical Company (Ann Arbor, MI, USA) |
| Assay Data | None |
| Validation Techniques used | ELISA |
| Up Regulation Down Regulation | Increase |
| Sequence Data | None |
| External Link | None |
